GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1008375 | 1 | rs12507142 | chr4:17656103 | MED28 | chr4:17616273-17629791:+ | 0.13 | 3.38 | 0.000754 | Parasitemia in Tripanosoma cruzi seropositivity |
| BRCA | cis | rs11097912 | 1 | rs12509366 | chr4:107003343 | TBCK | chr4:106967233-107237861:- | 0.26 | 7.92 | 5.88E-15 | Airflow obstruction |
| BRCA | cis | rs11097912 | 1 | rs12509640 | chr4:106996677 | TBCK | chr4:106967233-107237861:- | -0.23 | -6.96 | 5.84E-12 | Airflow obstruction |
| BRCA | cis | rs11097912 | 1 | rs12510966 | chr4:106983604 | TBCK | chr4:106967233-107237861:- | 0.26 | 7.98 | 3.68E-15 | Airflow obstruction |
| BRCA | cis | rs7692995 | 1 | rs12511456 | chr4:17975603 | NCAPG | chr4:17812525-17846485:+ | 0.09 | 4.4 | 1.21E-5 | Height |
| BRCA | cis | rs7692995 | 1 | rs12511600 | chr4:17939921 | NCAPG | chr4:17812525-17846485:+ | 0.08 | 3.96 | 8.13E-5 | Height |
| BRCA | cis | rs1364989 | 1 | rs12512002 | chr4:55016790 | FIP1L1 | chr4:54243820-54326102:+ | -0.19 | -4.25 | 2.37E-5 | Lupus nephritis in systemic lupus erythematosus |
| BRCA | cis | rs4691139 | 1 | rs12512283 | chr4:165908927 | TRIM61 | chr4:165875600-165898818:- | 0.24 | 7.55 | 9.01E-14 | Ovarian cancer in BRCA1 mutation carriers |
| BRCA | cis | rs11097912 | 1 | rs12512683 | chr4:106999471 | TBCK | chr4:106967233-107237861:- | 0.23 | 7.18 | 1.27E-12 | Airflow obstruction |
| BRCA | cis | rs7692995 | 1 | rs12513324 | chr4:18006951 | NCAPG | chr4:17812525-17846485:+ | 0.08 | 3.73 | 0.000204 | Height |
| BRCA | cis | rs10043228 | 1 | rs12514600 | chr5:115470655 | COMMD10 | chr5:115420727-115628978:+ | 0.27 | 5.11 | 3.81E-7 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12515308 | chr5:115450441 | COMMD10 | chr5:115420727-115628978:+ | 0.22 | 4.75 | 2.28E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12515466 | chr5:115591877 | COMMD10 | chr5:115420727-115628978:+ | 0.21 | 4.57 | 5.47E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs2036402 | 1 | rs12515585 | chr5:156430150 | TIMD4 | chr5:156346293-156390266:- | -0.16 | -4.15 | 3.54E-5 | Hypertriglyceridemia |
| BRCA | cis | rs10043228 | 1 | rs12516100 | chr5:115451750 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 4.77 | 2.08E-6 | Asthma or chronic obstructive pulmonary disease |